PROTECTION AGAINST THE LETHAL EFFECTS OF ORGANO-PHOSPHATES BY PYRIDINE-2-ALDOXIME METHIODIDE
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چکیده
منابع مشابه
A conjugate of pyridine-4-aldoxime and atropine as a potential antidote against organophosphorus compounds poisoning.
A conjugate of pyridine-4-aldoxime and atropine (ATR-4-OX) was synthesized and its antidotal efficiency was tested in vitro on tabun- or paraoxon-inhibited acetylcholinesterase (AChE) of human erythrocytes as well as in vivo using soman-, tabun- or paraoxon-poisoned mice. Its genotoxic profile was assessed on human lymphocytes in vitro and was found acceptable for further research. ATR-4-OX sho...
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15 صفحه اولBis(acetato-κO)bis(pyridine-2-aldoxime-κ2 N,N′)nickel(II)
In the mononuclear title compound, [Ni(CH(3)COO)(2)(C(6)H(6)N(2)O)(2)], the Ni(II) atom is coordinated by two pyridine-2-aldoxime (PaoH) ligands and two acetate groups, with cis coordination for the pairs of identical ligands. While each acetate group binds to the Ni(II) atom by one O atom, each PaoH chelates the Ni(II) atom through two N atoms. The O atom on PaoH is not deprotonated and does n...
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ژورنال
عنوان ژورنال: British Journal of Pharmacology and Chemotherapy
سال: 1957
ISSN: 0366-0826
DOI: 10.1111/j.1476-5381.1957.tb00162.x